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Research - Candida

Candida albicans is an opportunistic pathogenic yeast that is a common member of the human gut flora. It does not proliferate outside the human body.

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Mycoses. 2012 May;55(3):257-61. doi: 10.1111/j.1439-0507.2011.02079.x. Epub 2011 Sep 13.

Aloe vera extract reduces both  growth and germ tube formation by Candida albicans.

Bernardes I1Felipe Rodrigues MPBacelli GKMunin EAlves LPCosta MS.

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Abstract

Due to the increased number of immunocompromised patients, the infections associated with the pathogen of the genus Candida have significantly increased in recent years. To grow, Candida albicans may form a germ tube extension from the cells, which is essential for virulence. In this work, we studied the effect of crude glycolic extract of Aloe vera fresh leaves (20% w/v) on growth and germ tube formation by C. albicans. The C. albicans growth was determined in the presence of different concentrations of A. vera extracts in Sabouraud dextrose broth medium. In the presence of A. vera extract (10% v/v), the pronounced inhibition in the C. albicans growth (90-100%) was observed. This inhibition occurred parallel to the decrease in the germ tube formation induced by goat serum. Our results demonstrated that A. vera fresh leaves plant extract can inhibit both the growth and the germ tube formation by C. albicans.

Our results suggest the possibility that A. vera extract may be used as a promising novel antifungal treatment.

Published by: U.S Department of Health & Human Services National Institute of Health U.S National Library of Medicine.

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